On Linux, MDBTools is your only chance as of now. [disputed]
On Windows, you can deal with mdb files with pypyodbc.
To create an Access mdb file:
import pypyodbc
pypyodbc.win_create_mdb( "D:\\Your_MDB_file_path.mdb" )
Here is an Hello World script that fully demostate pypyodbc’s Access support functions.
Disclaimer: I’m the developer of pypyodbc.