What is the best/safest way to reinstall Homebrew?

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Update 10/11/2020 to reflect the latest brew changes.

Brew already provide a command to uninstall itself (this will remove everything you installed with Homebrew):

/bin/bash -c "$(curl -fsSL https://raw.githubusercontent.com/Homebrew/install/master/uninstall.sh)"

If you failed to run this command due to permission (like run as second user), run again with sudo

Then you can install again:

/bin/bash -c "$(curl -fsSL https://raw.githubusercontent.com/Homebrew/install/master/install.sh)"

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