Try this:
Drawable unwrappedDrawable = AppCompatResources.getDrawable(context, R.drawable.my_drawable);
Drawable wrappedDrawable = DrawableCompat.wrap(unwrappedDrawable);
DrawableCompat.setTint(wrappedDrawable, Color.RED);
Using DrawableCompat
is important because it provides backwards compatibility and bug fixes on API 22 devices and earlier.