As of Python 3.5, the standard way to do this (using the standard library) is with the math.isclose
function.
It has the following signature:
isclose(a, b, rel_tol=1e-9, abs_tol=0.0)
An example of usage with absolute error tolerance:
from math import isclose
a = 1.0
b = 1.00000001
assert isclose(a, b, abs_tol=1e-8)
If you want it with precision of n significant digits, simply replace the last line with:
assert isclose(a, b, abs_tol=10**-n)