How to Empty Caches and Clean All Targets Xcode 4 and later

Command-Option-Shift-K to clean out the build folder. Even better, quit Xcode and clean out ~/Library/Developer/Xcode/DerivedData manually. Remove all its contents because there’s a bug where Xcode will run an old version of your project that’s in there somewhere. (Xcode 4.2 will show you the Derived Data folder: choose Window > Organizer and switch to the Projects tab. Click the right-arrow to the right of the Derived Data folder name.)

In the simulator, choose iOS Simulator > Reset Content and Settings.

Finally, for completeness, you can delete the contents of /var/folders; some caching happens there too.

WARNING: Deleting /var/folders can cause issues, and you may need to repair or reinstall your operating system after doing so.

EDIT: I have just learned that if you are afraid to grapple with /var/folders/ you can use the following command in the Terminal to delete in a more targeted way:

rm -rf "$(getconf DARWIN_USER_CACHE_DIR)/org.llvm.clang/ModuleCache"

EDIT: For certain Swift-related problems I have found it useful to delete ~/Library/Caches/ You lose a lot when you do this, like your spare copies of the downloaded documentation doc sets, but it can be worth it.

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