How to set a binding in Code?

Replace:

myBinding.Source = ViewModel.SomeString;

with:

myBinding.Source = ViewModel;

Example:

Binding myBinding = new Binding();
myBinding.Source = ViewModel;
myBinding.Path = new PropertyPath("SomeString");
myBinding.Mode = BindingMode.TwoWay;
myBinding.UpdateSourceTrigger = UpdateSourceTrigger.PropertyChanged;
BindingOperations.SetBinding(txtText, TextBox.TextProperty, myBinding);

Your source should be just ViewModel, the .SomeString part is evaluated from the Path (the Path can be set by the constructor or by the Path property).

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