Windows:
In your Tomcat /bin folder, you should have a tomcat5w.exe admin app (or in later versions tomcat6w.ex, tomcat8w.exe, etc). Go to the Java tab and add the args in the “Java Options:” box.
Note that when you add new args, you need to add them as NEW LINES in that box (above or below any others there), not as additional arguments IN FRONT or BACK of values on one of the existing lines.
Linux / UNIX:
In *nix, changes to the setenv.sh file should be picked up:
export JAVA_OPTS=-server -Xms2g -Xmx4g -XX:PermSize=64m -XX:MaxPermSize=256m $JAVA_OPTS
Don’t touch catalina.sh or other files in bin