Use this as a workaround:
export CRYPTOGRAPHY_ALLOW_OPENSSL_098=1
This appears to be a recent check of the hazmat cryptography library. You can see the source code at:
The CRYPTOGRAPHY_ALLOW_OPENSSL_098
environment variable downgrades the error to a deprecation warning, if you are willing to take the risk. I also ran into this on OS X in just the past day, so something changed recently.