Python: Choose random line from file, then delete that line

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Point is: you dont “delete” from a file, but rewrite the whole file (or another one) with new content. The canonical way is to read the original file line by line, write back the lines you want to keep to a temporary file, then replace the old file with the new one.

with open("/path/to/source.txt") as src, open("/path/to/temp.txt", "w") as dest:
    for line in src:
        if should_we_keep_this_line(line):
            dest.write(line)
os.rename("/path/to/temp.txt", "/path/to/source.txt")

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