You just specify converters. I created an excel spreadsheet of the following structure:
names ages
bob 05
tom 4
suzy 3
Where the “ages” column is formatted as strings. To load:
import pandas as pd
df = pd.read_excel('Book1.xlsx',sheetname="Sheet1",header=0,converters={'names':str,'ages':str})
>>> df
names ages
0 bob 05
1 tom 4
2 suzy 3