replacing text in a file with Python

by

This should do it

replacements = {'zero':'0', 'temp':'bob', 'garbage':'nothing'}

with open('path/to/input/file') as infile, open('path/to/output/file', 'w') as outfile:
    for line in infile:
        for src, target in replacements.items():
            line = line.replace(src, target)
        outfile.write(line)

EDIT: To address Eildosa’s comment, if you wanted to do this without writing to another file, then you’ll end up having to read your entire source file into memory:

lines = []
with open('path/to/input/file') as infile:
    for line in infile:
        for src, target in replacements.items():
            line = line.replace(src, target)
        lines.append(line)
with open('path/to/input/file', 'w') as outfile:
    for line in lines:
        outfile.write(line)

Edit: If you are using Python 2.x, use replacements.iteritems() instead of replacements.items()

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