What is the best way to generate all possible three letter strings?

by 
keywords = itertools.product(alphabets, repeat = 3)

See the documentation for itertools.product. If you need a list of strings, just use

keywords = [''.join(i) for i in itertools.product(alphabets, repeat = 3)]

alphabets also doesn’t need to be a list, it can just be a string, for example:

from itertools import product
from string import ascii_lowercase
keywords = [''.join(i) for i in product(ascii_lowercase, repeat = 3)]

will work if you just want the lowercase ascii letters.

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