asp.net Button OnClick event not firing

Because your button is in control it could be that there is a validation from another control that don’t allow the button to submit.
The result in my case was to add CausesValidation property to the button:

<asp:Button ID="btn_QuaSave" runat="server" Text="SAVE" OnClick="btn_QuaSave_Click" CausesValidation="False"/> 

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