Genymotion, “Unable to load VirtualBox engine.” on Mavericks. VBox is setup correctly

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I had the same problem and solved it by running the following command:

sudo /Library/StartupItems/VirtualBox/VirtualBox restart

In later versions, the command is 

sudo /Library/Application\ Support/VirtualBox/LaunchDaemons/VirtualBoxStartup.sh restart

Make sure you’ve unblocked VirtualBox’s kernel extensions in System Preferences->Security and Privacy->General (You’ll get a popup when you install VirtualBox).

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