<ItemsControl ItemsSource="{Binding Numbers}">
<ItemsControl.ItemsPanel>
<ItemsPanelTemplate>
<!-- could use a WrapPanel if more appropriate for your scenario -->
<StackPanel Orientation="Horizontal"/>
</ItemsPanelTemplate>
</ItemsControl.ItemsPanel>
<ItemsControl.ItemTemplate>
<DataTemplate>
<StackPanel Orientation="Horizontal">
<TextBlock x:Name="commaTextBlock" Text=", "/>
<TextBlock Text="{Binding .}"/>
</StackPanel>
<DataTemplate.Triggers>
<DataTrigger Binding="{Binding RelativeSource={RelativeSource PreviousData}}" Value="{x:Null}">
<Setter Property="Visibility" TargetName="commaTextBlock" Value="Collapsed"/>
</DataTrigger>
</DataTemplate.Triggers>
</DataTemplate>
</ItemsControl.ItemTemplate>
</ItemsControl>
I arrived at your question because I was looking for a solution in Silverlight, which does not have a previous data relative source.