Is it possible to assign the same value to multiple keys in a dict object at once?

I would say what you have is very simple, you could slightly improve it to be:

my_dict = dict.fromkeys(['a', 'c', 'd'], 10)
my_dict.update(dict.fromkeys(['b', 'e'], 20))

If your keys are tuple you could do:

>>> my_dict = {('a', 'c', 'd'): 10, ('b', 'e'): 20}
>>> next(v for k, v in my_dict.items() if 'c' in k)      # use .iteritems() python-2.x
10

This is, of course, will return first encountered value, key for which contains given element.

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