WPF + MVVM + RadioButton : How to handle binding with single property?

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You need a IValueConverter.

//define this in the Window's Resources section or something similiarly suitable
<local:GenderConverter x:Key="genderConverterKey" />


<RadioButton Content="M" IsChecked="{Binding Gender, Converter={StaticResource ResourceKey=genderConverterKey}, ConverterParameter=M}" />
<RadioButton Content="F" IsChecked="{Binding Gender, Converter={StaticResource ResourceKey=genderConverterKey}, ConverterParameter=F}" />

The converter

public class GenderConverter : IValueConverter
{
    public object Convert(object value, Type targetType, object parameter, System.Globalization.CultureInfo culture)
    {
        return ((string)parameter == (string)value);
    }

    public object ConvertBack(object value, Type targetType, object parameter, System.Globalization.CultureInfo culture)
    {
        return (bool)value ? parameter : null;        
    }
}

Replace null (in ConvertBack) with Binding.DoNothing if binding should not be applied in that case.

return (bool)value ? parameter : Binding.DoNothing;

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