Make a div span two rows in a grid

You have fixed heights on your child elements (.block). Based on that information, we can extrapolate the height of the container (#wrapper).

By knowing the height of the container, your layout can be achieved using CSS Flexbox with flex-direction: column and flex-wrap: wrap.

A fixed height on the container serves as a breakpoint, telling flex items where to wrap.

#wrapper {
  display: flex;
  flex-direction: column;
  flex-wrap: wrap;
  height: 120px;
  width: 516px;
}
.block {
  width: 90px;
  flex: 0 0 50px;
  margin: 5px;
  background-color: red;
}
.bigger {
  flex-basis: 110px;
}
<div id="wrapper">
  <div class="block"></div>
  <div class="block"></div>
  <div class="block bigger"></div>
  <div class="block"></div>
  <div class="block"></div>
  <div class="block"></div>
  <div class="block"></div>
  <div class="block"></div>
  <div class="block"></div>
</div>

jsFiddle

Here’s an explanation why flex items can’t wrap unless there’s a fixed height/width on the container: https://stackoverflow.com/a/43897663/3597276

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