When index is unique, pandas use a hashtable to map key to value O(1). When index is non-unique and sorted, pandas use binary search O(logN), when index is random ordered pandas need to check all the keys in the index O(N).
You can call sort_index
method:
import numpy as np
import pandas as pd
x = np.random.randint(0, 200, 10**6)
df1 = pd.DataFrame({'x':x})
df2 = df1.set_index('x', drop=False)
df3 = df2.sort_index()
%timeit df1.loc[100]
%timeit df2.loc[100]
%timeit df3.loc[100]
result:
10000 loops, best of 3: 71.2 µs per loop
10 loops, best of 3: 38.9 ms per loop
10000 loops, best of 3: 134 µs per loop